It has worked pretty well for me and has reduced my pain considerably. For anti-inflamatory action, apparently it's best to take it between meals, on an empty or semi empty stomach.
I take 3 caps per day, each 500 mg and 600 gdu. Gel dissolving units are the ticket with bromelain. 1800 per day is considered a serious dosage.
I have tried glucosamine sulfate which helped a smidgeon -- but I started bromelain at the end of July and noticed a difference within a week or two.