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Thanks Duane for the good info on NSAIDS.

Posted by Scott R on 11/22/99 at 00:00 (013046)

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Re: Thanks Duane for the good info on NSAIDS.

caryne on 11/23/99 at 00:00 (013048)

Duane, did they mention relefen? My Dr. gave me a two week sample of vioxx and a two week sample of relefen. I've gone the vioxx and I'm on the relefen right now...then whichever helped me the most she'll give me a prescription. We tried celebrex in Aug/Sept and it didn't do much for me.

Re: Thanks Duane for the good info on NSAIDS.

Duane E on 11/24/99 at 00:00 (013087)

There was no mention of Relafen. However Relafen is known (especially at the upper levels of its recommended dosage) to cause gastrointestinal(GI) problems. You might want to read the safety/information data sheet that comes with the product, or can be obtained from your pharmacist.

The only COX-2 enzyme inhibitor nonsteroidal anti-inflammatories currently on the market are Celebrex and Vioxx. The other NSAIDs also inhibit the COX-1 enzyme; which for the GI tract is the problem. The COX-1 enzyme is an enzyme that protects the lining of the stomach and the small intestine.

The article did say that traditional NSAIDs are approximately as efficacious as the COX-2 inhibitors; however the COX-2 inhibitors were superior with respect to GI safety. As noted in the first NSAID post (above) the COX-2 inhibitors are not completely GI safe.

Re: Thanks Duane for the good info on NSAIDS.

caryne on 11/23/99 at 00:00 (013048)

Duane, did they mention relefen? My Dr. gave me a two week sample of vioxx and a two week sample of relefen. I've gone the vioxx and I'm on the relefen right now...then whichever helped me the most she'll give me a prescription. We tried celebrex in Aug/Sept and it didn't do much for me.

Re: Thanks Duane for the good info on NSAIDS.

Duane E on 11/24/99 at 00:00 (013087)

There was no mention of Relafen. However Relafen is known (especially at the upper levels of its recommended dosage) to cause gastrointestinal(GI) problems. You might want to read the safety/information data sheet that comes with the product, or can be obtained from your pharmacist.

The only COX-2 enzyme inhibitor nonsteroidal anti-inflammatories currently on the market are Celebrex and Vioxx. The other NSAIDs also inhibit the COX-1 enzyme; which for the GI tract is the problem. The COX-1 enzyme is an enzyme that protects the lining of the stomach and the small intestine.

The article did say that traditional NSAIDs are approximately as efficacious as the COX-2 inhibitors; however the COX-2 inhibitors were superior with respect to GI safety. As noted in the first NSAID post (above) the COX-2 inhibitors are not completely GI safe.